The GI tract is a finely balanced environment where roughly 500 different strains of bacteria compete for space and nutrients. When there is a healthy balance (eubiosis), few symptoms exist. However, dysbiosis can occur when an overabundance of potentially harmful organisms prevail. The natural microflora balance can be upset by medications (such as antibiotics, oral contraceptives, etc.), excessive alcohol consumption, or poor dietary intake.
Because probiotics are live organisms, there are many challenges associated with manufacturing and distributing probiotic supplements. For a probiotic to be effective, it must be shelf-stable through the expiration date and precisely delivered to the intestinal tract, where it can have maximum benefit. BioShield® technology is an innovative manufacturing process developed to ensure consistent and reliable results. The microorganisms in GI Calm Probiotic are protected, sealed and freeze dried away from moisture, heat, light and oxygen. This allows the bacteria to remain dormant until they are exposed to moisture in the GI tract. By utilizing advanced encapsulation technology, the probiotic organisms are preserved and released on-target for maximum benefit.
GI Calm Probiotic is a unique probiotic formula designed to deliver active organisms shown to promote healthy gut microflora, protect intestinal integrity and boost immune function. Included in this formula is Saccharomyces boulardii, an extensively researched microorganism shown to help restore microflora balance by enhancing commensal organism function. Each GI Calm Probiotic capsule provides seven proven probiotic strains chosen for their ability to withstand the harsh gastrointestinal (GI) environment and adhere to the intestinal tract to deliver superior results.
Lactobacillus acidophilus is a beneficial bacterial strain that is normally found in the intestinal tract and mouth and is commercially used in dairy products for the production of acidophilus-type yogurt. L. acidophilus ferments various carbohydrates to produce lactic acid, which increases the absorption and bioavailability of minerals. This includes calcium, copper, magnesium and manganese. The production of lactic acid also promotes health by creating an inhospitable environment for invading microbes. L. acidophilus has been shown to protect intestinal cells by competing for adhesion space in the gut against harmful bacteria, such as E. coli. The L. acidophilus strain in Ortho Biotic has been specifically chosen because of its strong adherence and survival attributes in the GI tract. It has been demonstrated in vitro to tolerate exposure to gastric acid and bile salts, and has the ability to withstand antibiotics including Ciproflaxin, Polymyxin B and Tetracycline.
Lactobacillus paracasei (Lpc-37)
Lactobacillus paracasei has been shown to protect against the harmful effects of bacteria such as Staphylococcus aureus (S. aureus). L. paracasei colonizes the intestinal tract by reinforcing defense mechanisms that support an immune response. It does this by supporting T-helper cell production and secreting secretory IgA (sIgA), an antibody critical for supporting intestinal immunity. L. paracasei Lpc-37 is a gastric acid-resistant strain and has been shown in vitro to withstand antibiotics such as Ciproflaxin and Vancomycin.
Bifidobacterium bifidum (Bb-02)
Bifidobacterium bifidum has been shown to effectively compete with harmful bacteria such as E. coli, S. aureus and Camplylobacter jejuni, which suggests B. bifidum’s lactic acid and acetic acid production provides an antagonistic action against pathogens to help maintain microflora balance.
Bifidobacterium lactis (BI-04)
Bifidobacterium lactis is predominantly found in the colon. A double-blind, randomized placebo-controlled trial on subjects receiving B. lactis or placebo for eight weeks found that B. lactis supported a balanced immune response in individuals hypersensitive to environmental allergens. Studies examining immune development and dietary supplementation with B. lactis have shown that it supports GI health by reducing intestinal permeability.
Lactobacillus plantarum (Lp-115)
Lactobacillus plantarum is a beneficial bacteria commonly found in fermented foods including sauerkraut, pickles, brined olives and sourdough. L. plantarum has been found to compete against strains of Clostridium difficile and Clostridium perfringens, due to the production of bacteriocins (lethal proteins) that inhibit bacterial growth. Studies have also demonstrated that L. plantarum helps boost the immune response by stimulating Th1-mediated immunity.
Lactobacillus rhamnosus (GG)
Lactobacillus rhamnosus has been proven to have remarkable survivability in the acid and bile environments in the GI tract. L. rhamnosus is particularly useful because of its ability to adhere to cells, enhance microflora balance, and inhibit pathogen adherence. L. rhamnosus was also found to positively affect inflammatory and immune gene signaling of over 1,700 genes when administered in high doses.
Saccharomyces boulardii
Saccharomyces boulardii is a probiotic yeast that was first isolated from the skin of the tropical fruits lychee and mangosteen in 1923 by French scientist Henri Boulard, following the observation that mangosteen consumption controlled occasional diarrhea in natives of Southeast Asia. S. boulardii plays a role in supporting immune defense by increasing levels of sIgA, creating a first line of defense that helps bind and clear harmful bacteria.
Liposomal delivery for immediate systemic absorption and bioavailability from the oral cavity.
Assists in the delivery of broad-spectrum botanicals to the central nervous system, a key benefit as nutritional support in Lyme disease or other microbial challenges outside the GI tract.
Researched for intracellular absorption of ingredients.
Enhances lymphatic circulation of therapeutic compounds.
Unilamellar vesicles encapsulating Biocidin® have an optimal particle size of 100 nanometers.
Research indicates potential in addressing biofilms and chronic/resistant cases of imbalanced terrain.
Includes botanicals to assist detoxification pathways and to address inflammation.
Shown to be beneficial in promoting a healthy gut terrain by detoxifying the bowel. The ingredients in Bowel Detox Sustained-Release Tablets have been shown to be anti-fungal, anti-bacterial, anti-viral, and anti-parasitic.
Meriva 500-SF helps maintain a healthy inflammatory response throughout the body. Meriva is the most clinically studied curcumin on the market with 29x greater absorption than ordinary curcumin.
Sacro-B (Saccharomyces boulardii) is a yeast species that enhances immune function in the gut by increasing sIgA and is effective for antibiotic-associated diarrhea.
FiberMend is a blend of soluble fiber that helps maintain healthy glycemic control and promote regularity and optimal digestive function. It mixes easily in water or a preferred beverage.
DIGESTION SUPPORT: Betaine Hydrochloride and pepsin (from porcine) aid in the proper digestion of proteins and food in the stomach.
INCREASE ABSORBABILITY: Gastric hydrochloric acid, a catalyst in the activation of pepsin from pepsinogen, also facilitates more soluble and absorbable divalent ferrous iron.
DIGESTIVE: Dietary supplement formulated to support G.I. health and its highly complex ecosystem.
